LS9, Inc.

LS9, Inc.

100 Kimball Way
South San Francisco, CA 94080

Fax: 650-589-1289


LS9, Inc., the Renewable Petroleum Company™, is a privately-held industrial biotechnology company based in South San Francisco, California developing patent-pending biofuels made with the power of synthetic biology.

LS9 DesignerBiofuels™ products are customized to closely resemble petroleum fuels, engineered to be clean, renewable, domestically produced, and cost competitive with crude oil.

LS9 is the market leader for hydrocarbon biofuels and is rapidly commercializing and scaling up DesignerBiofuels™ products to meet market demands, including construction of a pilot facility leading to commercial availability. While initially focusing on fuels, LS9 will also develop sustainable industrial chemicals for specialty applications.

LS9 has the financial backing of venture capital firms Flagship Ventures, Khosla Ventures, and Lightspeed Venture Partners. The company’s scientific advisory board (SAB) includes leaders in the fields of synthetic biology, metabolic engineering, microbiology, enzymology, genomics, bioinformatics, and chemical engineering.


Petroleum, on which modern day society was built and is now dependent, is a diminishing resource with increasing environmental, political, and economic disadvantages.

The ideal alternative would be chemically identical to petroleum, allowing broad and rapid adoption, derived from renewable resources, scalable to support current and future demands, domestically derived, and cost competitive without subsidies.

LS9 has developed Renewable Petroleum™ technologies to meet this need.

Pushing the frontiers of synthetic biology and industrial biotechnology, LS9 has created industrial microbes that efficiently convert renewable feedstocks to a portfolio of “drop in compatible” hydrocarbon-based fuels and chemicals. LS9’s unique technology provides a means to genetically control the structure and function of its fuels, enabling a product portfolio that meets the diverse demands of the petroleum economy.

LS9 has developed a new means of efficiently converting fatty acid intermediates into petroleum replacement products via fermentation of renewable sugars. LS9 has also discovered and engineered a new class of enzymes and their associated genes to efficiently convert fatty acids into hydrocarbons. LS9 believes this pathway is the most cost, resource, and energy-efficient way to produce hydrocarbon biofuels and petroleum-replacement products. This translates into efficient land and feedstock use and directly addresses tensions between food versus fuel production.



In the last 41 minutes, the world consumed 100 million gallons of petroleum – the equivalent annual output of a commercial ethanol plant.

Worldwide demand for petroleum products is insatiable. In the United States alone, there are 200,000 miles of pipeline, 170,000 fueling stations, and 243 million registered vehicles – all optimized for petroleum-based transportation fuels. These powerful network effects reinforce the dominance of hydrocarbon fuels and necessitate second-generation biofuels that are compatible with this existing distribution and consumer infrastructure.

LS9 DesignerBiofuels™ products are a family of fuels produced by specially-engineered microbes created via industrial synthetic biology. Starting from raw, natural sources of sugar such as sugar cane and cellulosic biomass, these renewable fuels will fundamentally change the biofuels landscape and set the stage for widespread product adoption and petroleum displacement. LS9 hydrocarbon biofuels have higher energetic content than ethanol or butanol and have fuel properties that are essentially indistinguishable from those of gasoline, diesel, and jet fuel.

LS9’s technology provides a means to genetically control the structure and function of its fuels, enabling a product portfolio that meets the diverse demands of the petroleum economy. LS9 DesignerBiofuels™ products overcome a number of key challenges associated with first-generation biofuels, including infrastructure compatibility, product diversity, product economics, and quality consistency. LS9 products can go directly into vehicles or be further processed at a refinery. The products are designed to be cost-competitive with traditional petroleum products – without subsidies – and be commercially available within a few years.

Based on a highly efficient production method, LS9 products offer increased environmental benefits over production and refinement of crude oil and ethanol. LS9 DesignerBiofuels™ products approach carbon neutrality, with an equivalent amount of carbon dioxide consumed by the plant-based feedstocks as are generated from combustion of the fuels. In addition, LS9 products contain no carcinogens like benzene (commonly found in petroleum) and only trace amounts of sulfur.

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